Improved non-invasive T-Staging in non-small cell lung cancer by integrated 18F-FDG PET/CT.
Nuklearmedizin
; 46(1): 9-14; quiz N1-2, 2007.
Article
em En
| MEDLINE
| ID: mdl-17299649
ABSTRACT
AIM:
In this prospective study, reliability of integrated (18)F-FDG PET/CT for staging of NSCLC was evaluated and compared to MDCT or PET alone. PATIENTS,METHODS:
240 patients (pts) with suspected NSCLC were examined using PET/CT. Of those patients 112 underwent surgery comprising 80 patients with NSCLC (T1 n = 26, T2 n = 37, T3 n = 11, T4 n = 6). Imaging modalities were evaluated independently.RESULTS:
MDCT, PET and PET/CT diagnosed the correct T-stage in 40/80 pts (50%; CI 0.39-0.61), 40/80 pts (50%; CI 0.39-0.61) and 51/80 pts (64%; CI 0.52-0.74), respectively, whereas equivocal T-stage was found in 15/80 pts (19%; CI 0.11-0.19), 12/80 pts (15%; CI 0.08-0.25) and 4/80 pts (5%; CI 0.01-0.12), respectively. With PET/CT, T-stage was more frequently correct compared to MDCT (p = 0.003) or PET (p = 0.019). Pooling stages T1/T2, T-stage was correctly diagnosed with MDCT, PET and PET/CT in 54/80 pts (68%; CI 0.56-0.78), 56/80 pts (70%; CI 0.59-0.80) and 65/80 pts (81%; CI 0.71-0.89). T3 stage was most difficult to diagnose. T3 tumors were correctly diagnosed with MDCT in 2/11 pts (18%; CI 0.02-0.52) versus 0/11 pts (0%; CI 0.00-0.28) with PET and 5/11 pts (45%; CI 0.17-0.77) with PET/CT. In all imaging modalities, there were no equivocal findings for T4 tumors. Of these, MDCT found the correct tumor stage in 4/6 pts (67%; CI 0.22-0.95), PET in 3/6 pts (50%; CI 0.12-0.88) and PET/CT in 5/6 pts (83%; CI 0.36-0.99).CONCLUSION:
Integrated PET/CT was significantly more accurate for T-staging of NSCLC compared to MDCT or PET alone. The advantages of PET/CT are especially pronounced combining T1- and T2-stage as well as in advanced tumors.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma Pulmonar de Células não Pequenas
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Nuklearmedizin
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha