Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue.
J Exp Med
; 175(1): 65-70, 1992 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-1730927
ABSTRACT
The present study examined mechanisms of tolerance for T cell receptor gamma/delta (TCR-gamma/delta) cells. Using a transgenic (Tg) model, we demonstrate that although alloantigen (Ag)-specific TCR-gamma/delta cells are deleted in the thymus and spleen of Ag-bearing mice, intraepithelial lymphocytes (IELs) expressing normal levels of the Tg TCR were present. However, Tg+ IELs from Ag-bearing mice were unresponsive to activation. Furthermore, self-reactive Tg+ IELs decreased in number over time. Thus, in epithelial tissue, Tg TCR-gamma/delta cells are eliminated subsequent to and most likely as a result of the induction of clonal anergy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores de Antígenos de Linfócitos T
/
Linfócitos T
/
Tolerância Imunológica
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1992
Tipo de documento:
Article