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Solution structure of the lipophosphoglycan of Leishmania donovani.
Homans, S W; Mehlert, A; Turco, S J.
Afiliação
  • Homans SW; Department of Biochemistry, University of Dundee, Scotland, U.K.
Biochemistry ; 31(3): 654-61, 1992 Jan 28.
Article em En | MEDLINE | ID: mdl-1731920
The three-dimensional solution structure of the repeating -PO4-6Gal beta 1-4Man alpha 1- disaccharide fragment of the lipophosphoglycan (LPG) derived from Leishmania donovani has been determined by use of a combination of homo- and heteronuclear NMR spin coupling constant measurements together with restrained molecular mechanical minimization and molecular dynamics simulations. The fragment exists with limited mobility in solution about the Gal beta 1-4Man linkages, whereas in contrast a variety of stable rotamers exist about the Man alpha 1-PO4-6Gal linkages. These rotamers define several major stable conformers in solution, which are discussed in terms of the proposed biological role of LPG.
Assuntos
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Base de dados: MEDLINE Assunto principal: Leishmania donovani / Glicoesfingolipídeos Limite: Animals Idioma: En Revista: Biochemistry Ano de publicação: 1992 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Leishmania donovani / Glicoesfingolipídeos Limite: Animals Idioma: En Revista: Biochemistry Ano de publicação: 1992 Tipo de documento: Article