Structural differences between the two human complement C4 isotypes affect the humoral immune response.
J Exp Med
; 175(2): 537-43, 1992 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-1732415
ABSTRACT
An animal model has been used to address the question of the biological importance of the known structural difference between the two isotypes of human C4, i.e., C4A and C4B. Guinea pigs deficient in C4 were reconstituted transiently with either human C4A or C4B protein and immunized with the bacteriophage phi X174. Results from this study showed that C4A-reconstituted animals made a secondary response, i.e., switch from IgM to IgG; whereas the C4B-reconstituted animals did not.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Isotipos de Imunoglobulinas
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Complemento C4a
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Complemento C4b
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Formação de Anticorpos
Limite:
Animals
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Humans
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Male
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1992
Tipo de documento:
Article