Clonal spread of mef-positive macrolide-resistant Streptococcus pneumoniae isolates causing invasive disease in adults in Germany.
Antimicrob Agents Chemother
; 51(5): 1830-4, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17325214
ABSTRACT
Isolates (3,845) obtained from German adults with invasive pneumococcal disease between 1992 and 2004 were investigated. Of these, 430 isolates (11.2%) were erythromycin A nonsusceptible. Macrolide resistance genotypes and multilocus sequence types were determined. Among the isolates, 35.6% were erm(B) positive and 63.5% were mef positive. Over the study period, the frequency of resistance rose significantly from 2.2 to 17.0% (P < 0.001). A serotype 14, sequence type 9 clone was the most widespread.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
/
Streptococcus pneumoniae
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Proteínas de Bactérias
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Eritromicina
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Macrolídeos
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Proteínas de Membrana
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Antibacterianos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha