Establishment of the porcine epitheliochorial placenta is associated with endometrial T-cell recruitment.
Am J Reprod Immunol
; 57(4): 250-61, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17362386
ABSTRACT
PROBLEM:
We assessed implantation-associated quantitative changes in peripheral blood and endometrial T lymphocytes throughout epitheliochorial placenta formation. METHOD OF STUDY T-cell subsets were investigated in 10-, 15-, 20-, 30-, and 40-day pregnant and non-pregnant sows by flow cytometry and immunohistochemistry.RESULTS:
Endometrial total T, T cytotoxic (Tc), and T helper (Th) cells were in peak numbers at the attachment phase of implantation and Tc cells persisted in high proportions up to placental establishment. The number of gammadelta T lymphocytes was relatively small and implantation-independent. In situ, T cells increased in number with the advancement of implantation and formed T-cell clusters with implantation phase-dependent location. Percentages of peripheral blood T cells were not significantly changed throughout the implantation.CONCLUSION:
Superficial and adeciduate implantation of pigs has a profound effect on the number of total T, Tc, and Th cells and pattern of distribution of endometrial T cells in situ.
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Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Placenta
/
Linfócitos T
/
Quimiotaxia de Leucócito
/
Endométrio
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Am J Reprod Immunol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Bulgária