[The effect of MTHFR polymorphisms, pregnancy and first intercourse on cervical cancer in a population from the Northeastern Mexico]. / Interacciones entre polimorfismos del gen MTHFR, gestaciones e inicio de vida sexual modifican el riesgo para cáncer cérvico-uterino en una población del noreste de México.
Rev Invest Clin
; 58(5): 462-9, 2006.
Article
em Es
| MEDLINE
| ID: mdl-17408107
ABSTRACT
OBJECTIVE:
To investigate the possible association among MTHFR polymorfhisms, environmental factors and cervical cancer (CC) in the Mexican population.METHODS:
Seventy patients with CC and 89 control women were questioned about clinical data and their 677 and 1298 genotypes of MTHFR gene were analized.RESULTS:
Multipregnancies (0-2 vs. > or = 3, OR 2.1), an early age of first intercourse (IVS) (17 < or = vs. > or = 18 years, OR 4.3) or both factors (OR 3.5) were significantly associated with CC. MTHFR 677, 1298 polymorphisms and their combinations were not different between cases and controls. However, a significant association between pregnancies, IVS and MTHFR polymorphisms (presence of 1298C allele or 677TT genotype) was observed. The 1298C allele plus multipregnancies and IVS < or = 17 years, or both factors, increased 4.3, 5.3, and 11.8 times the risk for CC, respectively, while 677TT genotype changed the risk 2.0, 1.9, and 4.2 times, respectively.CONCLUSION:
The 1298C allele increases the risk of CC strongly in women with multipregnancies and early age of IVS, while 677TT genotype has a lower risk without becoming a protection factor.
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Base de dados:
MEDLINE
Assunto principal:
Paridade
/
Polimorfismo Genético
/
Neoplasias do Colo do Útero
/
Coito
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
/
Pregnancy
País/Região como assunto:
Mexico
Idioma:
Es
Revista:
Rev Invest Clin
Assunto da revista:
MEDICINA
Ano de publicação:
2006
Tipo de documento:
Article