Resialylation of sialic acid deficit vascular endothelium, circulating cells and macromolecules may counteract the development of atherosclerosis: a hypothesis.
Atherosclerosis
; 192(2): 243-5, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17420020
ABSTRACT
Deficit sialylation of vascular endothelium, circulating cells and macromolecules has been associated with the development of atherosclerosis. On the other hand, an elevated serum level of sialic acid is a long-lasting marker of atherosclerosis and complications from atherosclerosis. One may speculate that the inverse associations with atherosclerosis risk are due to some common underlying cause. One mission for the elevated serum sialic acid level might be to act as a substrate for resialylation of sialic acid deficit structures and thereby counteract the atherosclerotic process.
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Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
/
Ácido N-Acetilneuramínico
/
Aterosclerose
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Atherosclerosis
Ano de publicação:
2007
Tipo de documento:
Article