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Triple therapy of initial high-dose interferon with ribavirin and amantadine for patients with chronic hepatitis C.
Uyama, Hirokazu; Nakamura, Hideji; Hayashi, Eijiro; Ogawa, Hiroyuki; Enomoto, Hirayuki; Yoshida, Kenya; Okuda, Yorihide; Yamamoto, Mitsunari; Hada, Toshikazu; Hayashi, Norio.
Afiliação
  • Uyama H; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Hepatol Res ; 37(5): 325-30, 2007 May.
Article em En | MEDLINE | ID: mdl-17441804
AIMS: We previously reported the potential effect of combination therapy of an initial high-dose interferon (IFN) and amantadine on the eradication of HCV-RNA in patients with chronic hepatitis C. The additive effects of amantadine on interferon and ribavirin combination therapy remain controversial. In this study we investigated the efficacy of initial high-dose IFN with ribavirin and amantadine on the virological response in patients with chronic hepatitis C with a high viral load of genotype 1b. METHODS: Twenty-two patients with high viral loads of genotype 1b hepatitis C virus were enrolled in this pilot study. Patients were administered IFN-beta for four weeks and then IFN-alpha2b for 22 weeks with daily oral administration of ribavirin and amantadine. RESULTS: A sustained virological response (SVR) was shown in 31.8% (seven of 22 patients). With the naïve patients, the SVR rate was 21.4% (three of 14 patients). In patients who could not eradicate HCV-RNA by previous IFN monotherapy, the SVR rate was 50% (four of eight patients). CONCLUSION: Triple therapy with an initial high dose of IFN with ribavirin and amantadine may be effective, especially for chronic hepatitis C IFN-retreatment patients with a high viral load of genotype 1b.
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Base de dados: MEDLINE Idioma: En Revista: Hepatol Res Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Japão
Buscar no Google
Base de dados: MEDLINE Idioma: En Revista: Hepatol Res Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Japão