Human hepatocyte morphology and functions in a multibore fiber bioreactor.
Macromol Biosci
; 7(5): 671-80, 2007 May 10.
Article
em En
| MEDLINE
| ID: mdl-17457942
ABSTRACT
The viability and liver specific functions of human hepatocytes in a multibore fiber bioreactor are reported. Human hepatocytes were cultured in the intraluminal compartment of the bioreactor. Human hepatocytes on the membranes maintained their round shape and showed focal adhesions as sites of interaction with the membrane surface. Cells in the bioreactor expressed liver specific functions, including synthetic and detoxification activity up to 14 d of culture. The results demonstrate that human hepatocytes cultured in the multibore fiber bioreactor are able to sustain the same in vivo liver functions in vitro.
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Base de dados:
MEDLINE
Assunto principal:
Reatores Biológicos
/
Fígado Artificial
/
Hepatócitos
Limite:
Humans
Idioma:
En
Revista:
Macromol Biosci
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália