Determining membrane protein structures: still a challenge!
Trends Biochem Sci
; 32(6): 259-70, 2007 Jun.
Article
em En
| MEDLINE
| ID: mdl-17481903
ABSTRACT
Determination of structures and dynamics events of transmembrane proteins is important for the understanding of their function. Analysis of such events requires high-resolution 3D structures of the different conformations coupled with molecular dynamics analyses describing the conformational pathways. However, the solution of 3D structures of transmembrane proteins at atomic level remains a particular challenge for structural biochemists--the need for purified and functional transmembrane proteins causes a 'bottleneck'. There are various ways to obtain 3D structures X-ray diffraction, electron microscopy, NMR and modelling; these methods are not used exclusively of each other, and the chosen combination depends on several criteria. Progress in this field will improve knowledge of ligand-induced activation and inhibition of membrane proteins in addition to aiding the design of membrane-protein-targeted drugs.
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Base de dados:
MEDLINE
Assunto principal:
Conformação Proteica
/
Proteínas de Membrana
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França