Incidence and characterization of serum transaminases elevations in pegylated interferon and ribavirin treated patients with chronic hepatitis C.
Aliment Pharmacol Ther
; 25(11): 1293-300, 2007 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-17509097
ABSTRACT
BACKGROUND:
A virological response to pegylated-interferon and ribavirin is typically associated with a prompt fall in serum transaminases. For some patients, transaminases rise during treatment.AIM:
To assess the frequency and define factors associated with elevations of serum transaminases.METHODS:
A total of 169 treated patients were studied. Transaminase elevations were graded by WHO criteria - grade 0 no value > baseline, grade 1 1-2x baseline, grade 2 2.1-5x baseline, grade 3 >5x, grade 4 any rise with evidence of liver failure. Results 60/169 (35%) patients experienced transaminase elevations 52 grade 1, 6 grade 2, 1 grade 3, 1 grade 4. Overall, end of treatment response and sustained virological response rates were 72% and 55%. Lower rates were observed in the grade 1 elevation group (63% and 40%) compared with patients with grade 0 (79% and 65%) and grade > or =2 elevations (85% and 71%). Grade 1 elevations tended to occur earlier during treatment than grade > or =2 elevations. Transaminase elevations were associated with greater pre-treatment body weight (P = 0.006), steatosis (P = 0.008) and poorer sustained virological response rates (P = 0.007).CONCLUSIONS:
Transaminase elevations during treatment of chronic Hepatitis C virus with pegylated interferon and ribavirin are common but rarely severe. Mild rises may reflect ongoing viral activity in treatment non-responders. More significant rises are frequently observed despite a virological response, and may be because of an immuno-modulating effect of interferon in susceptible patients.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Ribavirina
/
Hepatite C Crônica
/
Transaminases
Tipo de estudo:
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Reino Unido