Regulatory considerations for determining postmarketing study commitments.
Clin Pharmacol Ther
; 82(2): 228-30, 2007 Aug.
Article
em En
| MEDLINE
| ID: mdl-17538552
ABSTRACT
Postmarketing Study Commitments (PMCs) are, most commonly, agreements made by pharmaceutical companies at the time of an FDA approval to perform a study or studies to elucidate further characteristics of the drug under consideration. The role of PMCs in drug regulation has come under considerable scrutiny in recent years, particularly as discussions of drug safety have intensified. Although these agreed-upon PMCs are described in FDA regulations, such PMCs are not sought by FDA with every approval, and completion of the agreed-upon studies is not a requirement for the drug's sponsor (there are required PMCs under certain regulatory provisions and these are discussed below). Requests by FDA at the time of regulatory approval for studies under PMCs have been a common practice for many years. When made, PMCs are described in the approval letters and are therefore publicly available. Concerns over whether PMCs were being duly performed, reported, and reviewed by FDA were addressed in the FDA Modernization Act of 1997, which required more detailed reporting by manufactures on their progress in meeting the PMCs and required FDA to report certain information publicly.
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Base de dados:
MEDLINE
Assunto principal:
Vigilância de Produtos Comercializados
/
Aprovação de Drogas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Clin Pharmacol Ther
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos