Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior.
EMBO J
; 26(12): 2991-3002, 2007 Jun 20.
Article
em En
| MEDLINE
| ID: mdl-17541406
ABSTRACT
Profilins are actin binding proteins essential for regulating cytoskeletal dynamics, however, their function in the mammalian nervous system is unknown. Here, we provide evidence that in mouse brain profilin1 and profilin2 have distinct roles in regulating synaptic actin polymerization with profilin2 preferring a WAVE-complex-mediated pathway. Mice lacking profilin2 show a block in synaptic actin polymerization in response to depolarization, which is accompanied by increased synaptic excitability of glutamatergic neurons due to higher vesicle exocytosis. These alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty-seeking behavior in profilin2 mutant mice. Our results highlight a novel, profilin2-dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Profilinas
/
Exocitose
/
Neurônios
Limite:
Animals
Idioma:
En
Revista:
EMBO J
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália