Lesion evolution after gamma knife irradiation observed by magnetic resonance imaging.
Int J Radiat Biol
; 83(4): 237-44, 2007 Apr.
Article
em En
| MEDLINE
| ID: mdl-17575951
ABSTRACT
PURPOSE:
Our study is focused on the magnetic resonance imaging (MRI) observation of lesion development and hippocampus related functional impairments in rats after irradiation with a Leksell Gamma knife (LGK). MATERIALS ANDMETHODS:
We exposed 32 three-month-old Long-Evans rats to various radiation doses (25 Gy, 50 Gy or 75 Gy). The rats were scanned by a 4.7 T magnetic resonance (MR) spectrometer at several timepoints (1 - 18 months) after irradiation. The lesion size was evaluated by manual segmentation; the animals were behaviorally tested in a Morris water maze and examined histologically.RESULTS:
We found that a dose of 25 Gy induced no edema, necrosis or behavioral change. The response of the rats to higher doses was not uniform; the first occurrence of lesions in the rat brains irradiated with 50 and 75 Gy was detected six months post-irradiation. Functional impairment correlated well with the lesion size and histology.CONCLUSIONS:
Rat brains showed the development of expanding delayed lesions after 50 or 75 Gy doses from the LGK during the first year after irradiation.
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Base de dados:
MEDLINE
Assunto principal:
Lesões por Radiação
/
Radiocirurgia
/
Hipocampo
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Int J Radiat Biol
Assunto da revista:
RADIOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
República Tcheca