Ultrastructural evidence of Tropheryma whippelii in PAS-negative granulomatous lymph nodes.
Ultrastruct Pathol
; 31(2): 169-72, 2007.
Article
em En
| MEDLINE
| ID: mdl-17613996
ABSTRACT
The presence of Tropheryma whippelii was demonstrated in the PAS-negative mesenteric granulomatous lymph nodes of a patient affected by Whipple disease. Ultrastructurally a few bacteria, enclosed by a membrane characteristic of Tropheryma whippelii, were found in the extracellular spaces and remnants of bacteria were found in the phagocytic vacuoles of macrophages. The scarce number of bacilli, probably due to the fact that the disease was at an initial phase, could explain the absence of PAS positivity. This case confirms the role of the electron microscopy in the diagnosis of Whipple disease, especially for extra-intestinal lesions and at the initial phase of the disease, when the characteristic PAS-positive macrophages can be absent.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Actinobacteria
/
Granuloma
/
Doença de Whipple
/
Linfonodos
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ultrastruct Pathol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália