Efficacy of moclobemide in a rat model of neurotoxicant-induced edema.
Can J Physiol Pharmacol
; 85(5): 556-61, 2007 May.
Article
em En
| MEDLINE
| ID: mdl-17632591
ABSTRACT
The potent antidepressant effect of moclobemide, a selective and reversible type A monoamine oxidase (MAO) inhibitor, is clinically established. In view of the ongoing debate on the neuroprotective properties of MAO inhibitors, the present study was undertaken to further define the protective effect of moclobemide in a rat model of neurotoxicant-induced edema. In this model, daily oral triethyltin (TET) administration for 5 consecutive days strongly perturbed the rat behaviour and induced a cerebral edema at the 5th day. Oral coadministration of moclobemide (2 x 100 mg.kg-1.day-1) with TET blocked the development of brain edema and the increase in the cerebral chloride content induced by TET. Moreover, moclobemide reduced the increase in the cerebral sodium content and attenuated the neurological deficit. In conclusion, moclobemide possesses potent protective properties in this rat model of cerebral edema, suggesting potential clinical utility as a neuroprotectant.
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Base de dados:
MEDLINE
Assunto principal:
Compostos de Trietilestanho
/
Edema Encefálico
/
Moclobemida
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Can J Physiol Pharmacol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França