[HIV-1 Rev and related inhibitors].
Yao Xue Xue Bao
; 42(4): 347-51, 2007 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-17633198
ABSTRACT
HIV-1 Rev is an indispensable regulatory factor of the virion protein expression. The interaction between Rev and RRE RNA accelerates the nuclear export of viral mRNA. The unspliced and singly spliced mRNA will be degraded in the absence of Rev, resulting in the interception of HIV-1 replication at the same time. The pivotal role that Rev plays in HIV-1 replication as a trans-acting factor makes it a new target in the research of AIDS drugs. In this review, the function of Rev, Rev-RRE interaction, as well as their related inhibitors are reported.
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Base de dados:
MEDLINE
Assunto principal:
Replicação Viral
/
HIV-1
/
Fármacos Anti-HIV
/
Produtos do Gene rev do Vírus da Imunodeficiência Humana
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China