Chlorpheniramine binding to human serum albumin by fluorescence quenching measurements.
Biochimie
; 73(5): 551-6, 1991 May.
Article
em En
| MEDLINE
| ID: mdl-1764499
ABSTRACT
The binding of chlorpheniramine to human serum albumin has been studied by fluorescence quenching, as a function of temperature; the experimental data could only be fitted to the Stern-Volmer modified equation. A statistical analysis of the results was performed in order to determine the significance of the constants calculated by this equation, as well as their thermodynamic parameters. The chlorpheniramine binding to human serum albumin accounts for almost half of the binding of this antihistaminic agent to human plasma proteins.
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Base de dados:
MEDLINE
Assunto principal:
Albumina Sérica
/
Clorfeniramina
Limite:
Humans
Idioma:
En
Revista:
Biochimie
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Espanha