Distal sensory polyneuropathy in the context of HIV/AIDS.
J Assoc Nurses AIDS Care
; 18(4): 32-40, 2007.
Article
em En
| MEDLINE
| ID: mdl-17662922
ABSTRACT
Peripheral neuropathy, or distal sensory polyneuropathy (DSPN), is the most common neurological problem in HIV disease. DSPN also represents a complex symptom that occurs because of peripheral nerve damage related to advanced HIV disease and in association with the use of antiretroviral therapy-particularly in individuals treated with dideoxynucleosides. Although DSPN is a frequent symptom, the specific pathophysiology is not well understood. The HIV-related neuropathies are commonly categorized as distal sensory polyneuropathies, although antiretroviral toxic neuropathies are described in the literature. Recently, mitochondrial toxicity has been identified as a possible etiology of DSPN. As individuals with HIV/AIDS survive longer, often living for decades with the disease, chronic symptoms like DSPN must be addressed. Pharmacologic approaches, complementary therapies, and self-care behaviors that may improve quality of life and limit symptoms of DSPN are important interventions for clinicians and those living with HIV/AIDS to consider in the management of peripheral neuropathy.
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Base de dados:
MEDLINE
Assunto principal:
Polineuropatias
/
Infecções por HIV
/
Terapia Antirretroviral de Alta Atividade
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Assoc Nurses AIDS Care
Assunto da revista:
ENFERMAGEM
/
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos