Asymmetric cell divisions of human hematopoietic stem and progenitor cells meet endosomes.
Cell Cycle
; 6(18): 2201-4, 2007 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-17671435
ABSTRACT
Hematopoietic stem cells (HSC) are undifferentiated cells, which self-renew over a long period of time and give rise to committed hematopoietic progenitor cells (HPC) containing the capability to replenish the whole blood system. Since both uncontrolled expansion as well as loss of HSC would be fatal, the decision of self-renewal versus differentiation needs to be tightly controlled. There is good evidence that both HSC niches as well as asymmetric cell divisions are involved in controlling whether HSC self-renew or become committed to differentiate. In this context, we recently identified four proteins which frequently segregate asymmetrically in dividing HSC/HPC. Remarkably, three of these proteins, the tetraspanins CD53 and CD63, and the transferrin receptor are endosome-associated proteins. Here, we highlight these observations in conjunction with recent findings in model organisms which show that components of the endosomal machinery are involved in cell-fate specification processes.
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Base de dados:
MEDLINE
Assunto principal:
Endossomos
/
Células-Tronco Hematopoéticas
/
Divisão Celular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cell Cycle
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha