Statins and foam cell formation: impact on LDL oxidation and uptake of oxidized lipoproteins via scavenger receptors.
Biochim Biophys Acta
; 1771(9): 1117-24, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17690011
ABSTRACT
The uptake of oxidized lipoproteins via scavenger receptors and the ensuing formation of foam cells are key events during atherogenesis. Foam cell formation can be reduced by treatment with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins). The efficacy of statins is evidently due not only to their cholesterol-lowering properties, but also to lipid-independent pleiotropic effects. This review focuses on lipid-independent pleiotropic effects of statins that influence foam cell formation during atherogenesis, with special emphasis on oxidative pathways and scavenger receptor expression.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Hidroximetilglutaril-CoA Redutases
/
Aterosclerose
/
Receptores Depuradores
/
Células Espumosas
/
Lipoproteínas
/
Lipoproteínas LDL
Limite:
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Alemanha