Isocoumarin Derivatives from the Sea Squirt-derived Fungus Penicillium stoloniferum QY2-10 and the Halotolerant Fungus Penicillium notatum B-52.
Arch Pharm Res
; 30(7): 816-9, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17703731
ABSTRACT
Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5alpha, 8alpha-epidioxy-23-methyl-(22E, 24R)-ergosta-6, 22-dien-3beta-ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 microM.
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Base de dados:
MEDLINE
Assunto principal:
Penicillium chrysogenum
/
Urocordados
/
Isocumarinas
/
Antineoplásicos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2007
Tipo de documento:
Article