Combined double lung-liver transplantation for cystic fibrosis without cardio-pulmonary by-pass.
Am J Transplant
; 7(10): 2433-8, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17845577
ABSTRACT
Sequential bilateral single lung-liver transplantation (SBSL-LTx) is a therapeutic option for patients with end stage lung and liver disease (ESLLD) due to cystic fibrosis (CF). A few cases have been reported, all of them were performed with the use of cardio-pulmonary by-pass (CPB). We performed SBSL-LTx in three young men affected by CF. All the recipients had respiratory failure and portal hypertension with hypersplenism. Along with lung transplants, two patients received a whole liver graft and one an extended right graft from an in situ split liver. During transplantation neither CPB nor veno-venous by-pass (VVB) were employed. Immunosuppression was based on basiliximab, tacrolimus, steroids and azathioprine. The three recipients are alive with a median follow-up of 670 days (range 244-1,533). Combined SBSL-LTx is a complex but effective procedure for the treatment of ESLLD due to CF, not necessarily requiring the use of CPB or VVB.
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Base de dados:
MEDLINE
Assunto principal:
Ponte Cardiopulmonar
/
Transplante de Fígado
/
Transplante de Pulmão
/
Falência Hepática
/
Fibrose Cística
/
Pneumopatias
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Transplant
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Itália