Synthesis, properties, and perspectives of gem-diphosphono substituted-thiazoles.
Eur J Med Chem
; 43(5): 1015-24, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-17870210
ABSTRACT
A series of substituted arylidene thiazoles were allowed to react with Wittig-Horner (WH) reagent, tetraethyl methyl-1,1-bisphosphonate, to produce via Michael addition reaction the corresponding heteroarylmethylenebisphosphonates (BPs) in different yields according to the experimental conditions. Acid hydrolysis of the new BPs was undertaken to obtain the corresponding bisphosphonic acids. Prediction and the in vivo activity of the products in the rat adjuvant model are also discussed in terms of structure-activity relationships (SAR).
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Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Anti-Inflamatórios não Esteroides
/
Difosfonatos
/
Conservadores da Densidade Óssea
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Eur J Med Chem
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Egito