Screening of innate immune receptors in neurodegenerative diseases: a similar pattern.
Neurobiol Aging
; 30(5): 759-68, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-17905482
ABSTRACT
In Alzheimer's disease (AD), Parkinson's disease (PD), dementia with Lewy bodies (DLB) and amyotrophic lateral sclerosis (ALS), neuroinflammatory responses are considered to contribute to neuronal injury. Recently, the innate immune receptors, toll-like receptors (TLRs) and the LPS receptor (CD14) have been related to neurodegeneration. In this study, we systematically assessed the expression of most TLRs and CD14 in AD, PD/DLB and ALS using murine models of these diseases and human post-mortem brain tissues. A common upregulation of TLR2 and CD14 was found in all three animal models. While these two receptors could also be detected in AD patient tissues, they were absent from DLB and ALS tissues. This uniform pattern of innate immune response in animal models of neurodegenerative diseases clearly indicates that this response is part of a non-specific neuroinflammatory effector phase rather than a disease-specific event. The less dynamic disease progression in humans and the location (extracellular versus intracellular) of the aggregated proteins deposits might explain the divergent results seen between animal models and human tissues.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Receptores de Lipopolissacarídeos
/
Doenças Neurodegenerativas
/
Encefalite
/
Receptores Toll-Like
/
Imunidade Inata
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha