ISCOMATRIX adjuvant for prophylactic and therapeutic vaccines.
Expert Rev Vaccines
; 6(5): 761-72, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-17931156
ABSTRACT
The ISCOMATRIX adjuvant has antigen-delivery and -presentation properties, as well as immunomodulatory capabilities that combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as both CD4+ and CD8+ T cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have been evaluated in clinical trials. The results of these completed and ongoing studies indicate that the ISCOMATRIX adjuvant is safe and generally well tolerated and increases the vaccine immune responses.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipídeos
/
Saponinas
/
Vacinas
/
Adjuvantes Imunológicos
/
Colesterol
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Expert Rev Vaccines
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Austrália