Incomplete synthesis of the Sda/Cad blood group carbohydrate in gastrointestinal cancer.
Biochim Biophys Acta
; 1780(3): 467-71, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-17961927
ABSTRACT
Cancer-associated changes in cell surface carbohydrates, including incomplete synthesis of normal carbohydrate epitopes, strongly affect malignant and metastatic potential. Here, we report that compensating for the cancer-associated loss of a single glycosyltransferase, beta1,4N-acetylgalactosaminyltransferase T2, dramatically decreased cell surface expression of both E-selectin ligands (sialyl Lewis(x) and sialyl Lewis(a)). This modification was associated with elevated expression of the Sd(a) carbohydrate determinant, which is expressed in normal gastrointestinal mucosa and is strikingly downregulated in cancer tissues. Loss of E-selectin ligands resulted in decreased adhesion of cancer cells to activated human endothelial cells in vitro and eventually suppressed metastatic potential in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Grupos Sanguíneos
/
Neoplasias Gastrointestinais
/
Antígenos do Grupo Sanguíneo de Lewis
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão