B-type natriuretic peptide and left ventricular dysfunction on exercise echocardiography in patients with chronic aortic regurgitation.
Heart
; 94(7): 897-902, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-17974697
ABSTRACT
OBJECTIVE:
To determine whether plasma levels of B-type natriuretic peptide (BNP) predict left ventricular (LV) dysfunction on exercise echocardiography in patients with moderate to severe aortic regurgitation (AR).DESIGN:
Case-control study.SETTING:
Outpatient cardiology departments. PATIENTS 39 asymptomatic or mildly symptomatic patients with chronic moderate to severe AR and a normal LV ejection fraction (>50%), and 10 normal controls. MAIN OUTCOMEMEASURES:
Plasma level of BNP and echocardiographic measures of LV function at rest and immediately after treadmill exercise.RESULTS:
LV end systolic volume index (LVESVI) was significantly increased in AR patients with normal BNP (CONCLUSIONS:
In moderate to severe AR compensatory LV remodelling can occur with no increase in plasma BNP. Increased BNP is associated with more severe regurgitation and changes consistent with early LV dysfunction on exercise echocardiography.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Insuficiência da Valva Aórtica
/
Disfunção Ventricular Esquerda
/
Peptídeo Natriurético Encefálico
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Humans
/
Middle aged
Idioma:
En
Revista:
Heart
Assunto da revista:
CARDIOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Nova Zelândia