The immune response to respiratory syncytial virus infection: friend or foe?
Clin Rev Allergy Immunol
; 34(2): 163-73, 2008 Apr.
Article
em En
| MEDLINE
| ID: mdl-17985249
ABSTRACT
The immune response to respiratory syncytial virus (RSV) infection has fascinated and frustrated investigators for decades. After adverse responses to early attempts at vaccination, it became popularly held that disease following infection was related to overly aggressive immune responses. However, recent data illustrate that severe forms of disease are related to inadequate, rather than hyperresponsive, adaptive immune reactions. Thus, recovery from primary (and perhaps later) RSV infection is dependent on the quality of innate immune responses. These findings should have enormous significance to the development of vaccines and antiviral compounds.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Infecções Respiratórias
/
Citocinas
/
Vírus Sincicial Respiratório Humano
/
Infecções por Vírus Respiratório Sincicial
/
Receptores Toll-Like
Limite:
Humans
/
Infant
Idioma:
En
Revista:
Clin Rev Allergy Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos