Somatostatinergic systems in brain: networks and functions.
Mol Cell Endocrinol
; 286(1-2): 75-87, 2008 May 14.
Article
em En
| MEDLINE
| ID: mdl-17997029
ABSTRACT
Somatostatin is abundantly expressed in mammalian brain. The peptide binds with high affinity to six somatostatin receptors, sst1, sst2A and B, sst3 to 5, all belonging to the G-protein-coupled receptor family. Recent advances in the neuroanatomy of somatostatin neurons and cellular distribution of sst receptors shed light on their functional roles in the neuronal network. Beside their initially described neuroendocrine role, somatostatin systems subserve neuromodulatory roles in the brain, influencing motor activity, sleep, sensory processes and cognitive functions, and are altered in brain diseases like affective disorders, epilepsia and Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Somatostatina
/
Receptores de Somatostatina
/
Neurotransmissores
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mol Cell Endocrinol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França