Assessing the safety of anthrax immunization in US Army aircrew members via physical examination.
J Occup Environ Med
; 49(10): 1079-85, 2007 Oct.
Article
em En
| MEDLINE
| ID: mdl-18000413
ABSTRACT
OBJECTIVE:
Anthrax in weaponized form is the bioterrorism agent of most concern. Questions raised about the safety of the anthrax vaccine can be addressed by comparing immunized and unimmunized people in population-based studies.METHODS:
A retrospective evaluation of data from periodic physical examinations collected on anthrax-immunized and -unimmunized US Army aircrew members between 1998 and 2005 was performed to evaluate the safety of anthrax immunization. Mean changes in variables found on physical examination and laboratory analysis were compared by use of t tests. Multiple linear regression predicted change in outcome from baseline characteristics.RESULTS:
We compared 6,820 immunized subjects and 4,145 unimmunized controls based on US Army aircrew physical examination and screening laboratory tests. No association between anthrax immunization and a clinically relevant change in a tested physiologic parameter was detected.CONCLUSIONS:
No attributable risk of anthrax immunization was observed in this group of Army aircrew members.
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Base de dados:
MEDLINE
Assunto principal:
Exame Físico
/
Aviação
/
Imunização
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Antraz
/
Militares
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
America do norte
Idioma:
En
Revista:
J Occup Environ Med
Assunto da revista:
MEDICINA OCUPACIONAL
/
SAUDE AMBIENTAL
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos