Age-related changes in cell surface antigens of preleukemic AKR thymocytes.
J Exp Med
; 144(1): 193-208, 1976 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-180229
ABSTRACT
Thymocytes from preleukemic AKR mice aged 5-6 mo have an altered pattern of cell surface antigens. The expression of four MuLV-related antigens on the cell surface (GIX, GCSA, gp70, p30) is markedly increased in comparison to 2-mo-old AKR mice and approximates the heightened levels of these antigens found on thymic leukemia cells. H-2 and Thy-1 alloantigens also show characteristic modifications in relation to age and leukemia development. In contrast to the high Thy-1/low H-2 levels on 2-mo-old AKR thymocytes, thymocytes from 6-mo-old mice and thymic leukemia cells frequently show a low Thy-1/high H-2 surface phenotype. As thymocytes from mouse strains with a low incidence of leukemia do not show these changes, they appear to represent a stage in the conversion of normal cells to leukemia cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
/
Envelhecimento
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Leucemia Experimental
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Camundongos Endogâmicos AKR
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Antígenos de Neoplasias
/
Antígenos Virais
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1976
Tipo de documento:
Article