Effects of naltrexone on electrocutaneous pain in patients with hypertension compared to normotensive individuals.
Biol Psychol
; 77(2): 191-6, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18031920
ABSTRACT
An opioid mechanism may help explain hypertensive hypoalgesia. A double-blind placebo-controlled design compared the effects of opioid blockade (naltrexone) and placebo on electrocutaneous pain threshold, pain tolerance, and retrospective McGill Pain Questionnaire ratings in 35 unmedicated patients with essential hypertension and 28 normotensive individuals. The hypertensives experienced less pain than normotensives during the assessment of their pain tolerance; however, this manifestation of hypertensive hypoalgesia was not moderated by naltrexone. These findings fail to support the hypothesis that essential hypertension is characterised by relative opioid insensitivity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Hipertensão
/
Naltrexona
/
Antagonistas de Entorpecentes
Tipo de estudo:
Clinical_trials
/
Qualitative_research
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Biol Psychol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Reino Unido