Understanding the neural computations of arbitrary visuomotor learning through fMRI and associative learning theory.
Cereb Cortex
; 18(7): 1485-95, 2008 Jul.
Article
em En
| MEDLINE
| ID: mdl-18033767
ABSTRACT
Associative theory postulates that learning the consequences of our actions in a given context is represented in the brain as stimulus-response-outcome associations that evolve according to prediction-error signals (the discrepancy between the observed and predicted outcome). We tested the theory on brain functional magnetic resonance imaging data acquired from human participants learning arbitrary visuomotor associations. We developed a novel task that systematically manipulated learning and induced highly reproducible performances. This granted the validation of the model-based results and an in-depth analysis of the brain signals in representative single trials. Consistent with the Rescorla-Wagner model, prediction-error signals are computed in the human brain and selectively engage the ventral striatum. In addition, we found evidence of computations not formally predicted by the Rescorla-Wagner model. The dorsal fronto-parietal network, the dorsal striatum, and the ventrolateral prefrontal cortex are activated both on the incorrect and first correct trials and may reflect the processing of relevant visuomotor mappings during the early phases of learning. The left dorsolateral prefrontal cortex is selectively activated on the first correct outcome. The results provide quantitative evidence of the neural computations mediating arbitrary visuomotor learning and suggest new directions for future computational models.
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Base de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
/
Aprendizagem por Associação
/
Córtex Visual
/
Mapeamento Encefálico
/
Imageamento por Ressonância Magnética
/
Modelos Neurológicos
/
Córtex Motor
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Cereb Cortex
Assunto da revista:
CEREBRO
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
França