Distinctive role of central histamine H3 receptor in various orexigenic pathways.
Eur J Pharmacol
; 579(1-3): 229-32, 2008 Jan 28.
Article
em En
| MEDLINE
| ID: mdl-18037404
ABSTRACT
Despite the well-established role of histamine as an anorexigenic neurotransmitter, the role of histamine H(3) receptors in feeding behavior is controversial. Herein we investigated the role of histamine H(3) receptor on several orexigenic agents in mice. Thioperamide (histamine H(3) receptor inverse agonist) inhibited neuropeptide Y- and nociceptin-induced hyperphagia but had no effect on U-50488 (opioid kappa-receptor agonist)-induced hyperphagia. In contrast, imetit (histamine H(3) receptor agonist) inhibited U-50488-induced hyperphagia but augmented neuropeptide Y-induced hyperphagia while it did not alter nociceptin-induced hyperphagia. These results indicate distinctive roles of histamine H(3) receptors in various orexigenic pathways.
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Base de dados:
MEDLINE
Assunto principal:
Apetite
/
Hiperfagia
/
Receptores Histamínicos H3
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão