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Plasma cortisol and 11-deoxycortisol activity in depressed patients and normal volunteers.
Schweitzer, I; Tuckwell, V M; Maguire, K P; Tiller, J W; Harrison, L C; Davies, B M.
Afiliação
  • Schweitzer I; Department of Psychiatry, University of Melbourne, Australia.
Psychoneuroendocrinology ; 16(5): 375-82, 1991.
Article em En | MEDLINE | ID: mdl-1805291
ABSTRACT
Plasma cortisol and 11-deoxycortisol were measured in 30 depressed patients and 110 normal volunteers before and after a 1.0 mg dexamethasone suppression test (DST). Post-dexamethasone plasma cortisol, 11-deoxycortisol and the cortisol/11-deoxycortisol ratio were significantly higher in the depressives compared to the controls, even when age and sex were taken into account. Pre-dexamethasone plasma cortisol, post-dexamethasone cortisol, 11-deoxycortisol and their ratio were significantly higher in the cortisol nonsuppressors than in the suppressors. The measurement of post-dexamethasone 11-deoxycortisol and the ratio did not differentiate between endogenous and reactive depression. Using the normative data, we explored several methods for determining a criterion value to define abnormal post-dexamethasone plasma 11-deoxycortisol and the cortisol/11-deoxycortisol ratio in depressed patients. All showed poor sensitivity and a low positive predictive value for depression. The measurement of 11-deoxycortisol thus does not enhance the clinical utility of the DST.
Assuntos
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Base de dados: MEDLINE Assunto principal: Dexametasona / Hidrocortisona / Cortodoxona / Transtorno Depressivo Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Psychoneuroendocrinology Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Austrália
Buscar no Google
Base de dados: MEDLINE Assunto principal: Dexametasona / Hidrocortisona / Cortodoxona / Transtorno Depressivo Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Psychoneuroendocrinology Ano de publicação: 1991 Tipo de documento: Article País de afiliação: Austrália