A synthetic triacylated pseudo-dipeptide molecule promotes Th1/TReg immune responses and enhances tolerance induction via the sublingual route.
Vaccine
; 26(1): 108-18, 2007 Dec 21.
Article
em En
| MEDLINE
| ID: mdl-18063445
ABSTRACT
In this study, we tested two triacylated pseudo-dipeptidic molecules, OM-197-MP-AC and OM-294-BA-MP as candidate adjuvants for allergy vaccines. Both molecules induce human dendritic cell (h-DC) maturation and polarize naïve T cells toward the Th1 type with IFNgamma production. Only OM-294-BA-MP induces IL10 gene expression both in monocyte-derived DCs and CD4+ naïve T cells. Sublingual administration of OM-294-BA-MP plus the antigen enhances tolerance induction in BALB/c mice with established asthma to ovalbumin with an impact on both airways hyperresponsiveness and lung inflammation. Given its Th1/Treg polarizing properties, OM-294-BA-MP is a valid candidate for sublingual allergy vaccines.
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Base de dados:
MEDLINE
Assunto principal:
Adjuvantes Imunológicos
/
Dessensibilização Imunológica
/
Linfócitos T Reguladores
/
Células Th1
/
Dipeptídeos
/
Tolerância Imunológica
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França