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Association of interleukin-10 gene haplotypes with Pseudomonas aeruginosa airway colonization in cystic fibrosis.
Tesse, Riccardina; Cardinale, Fabio; Santostasi, Teresa; Polizzi, Angela; Mappa, Luigi; Manca, Antonio; De Robertis, Francesco; Silecchia, Ombretta; Armenio, Lucio.
Afiliação
  • Tesse R; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy. Electronic address: nucciatesse@hotmail.com.
  • Cardinale F; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Santostasi T; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Polizzi A; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Mappa L; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Manca A; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • De Robertis F; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Silecchia O; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
  • Armenio L; Department of Biomedicina dell'Età Evolutiva, Pediatrics Unit "S. Maggiore", University of Bari, Bari, Italy.
J Cyst Fibros ; 7(4): 329-332, 2008 Jul.
Article em En | MEDLINE | ID: mdl-18093884
ABSTRACT
We genotyped three polymorphisms of the promoter region of the interleukin-10 (IL-10) gene in 220 CF patients from the CF Center of Bari, and tested for an association between genetic variants of the cytokine and chronic airway colonization with Pseudomonas aeruginosa. We found that carriers of the high-IL-10-producing-GCC haplotype had significantly higher risk of chronic pulmonary infection with the pathogen.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Interleucina-10 / Polimorfismo de Nucleotídeo Único / Fibrose Cística Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Cyst Fibros Ano de publicação: 2008 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pseudomonas aeruginosa / Interleucina-10 / Polimorfismo de Nucleotídeo Único / Fibrose Cística Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Revista: J Cyst Fibros Ano de publicação: 2008 Tipo de documento: Article