An adaptive approach to designing comparative diagnostic accuracy studies.
J Biopharm Stat
; 18(1): 116-25, 2008.
Article
em En
| MEDLINE
| ID: mdl-18161544
ABSTRACT
Comparative diagnostic studies usually involve comparison of the area under receiver operating characteristic curves when biomarkers are measured on a continuous or ordinal scales. In designing such studies, specification of a number of nuisance parameters is often required to compute sample sizes. When these parameters are incorrectly specified, statistical power to detect a meaningful difference in area can be substantially adversely affected. We propose an adaptive method to calculate the sample size and show these procedures to be effective in controlling error rates.
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Base de dados:
MEDLINE
Assunto principal:
Projetos de Pesquisa
/
Modelos Estatísticos
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
J Biopharm Stat
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos