Modulating cortical excitability in acute stroke: a repetitive TMS study.
Clin Neurophysiol
; 119(3): 715-723, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18165149
ABSTRACT
OBJECTIVE:
Changes in cerebral cortex excitability have been demonstrated after a stroke and are considered relevant for recovery. Repetitive transcranial magnetic stimulation (rTMS) of the brain can modulate cerebral cortex excitability and, when rTMS is given as theta burst stimulation (TBS), LTP- or LTD-like changes can be induced. The aim of present study was to evaluate the effects of TBS on cortical excitability in acute stroke.METHODS:
In 12 acute stroke patients, we explored the effects of facilitatory TBS of the affected hemisphere and of inhibitory TBS of the unaffected hemisphere on cortical excitability to single-pulse transcranial magnetic stimulation (TMS) on both sides. The effects produced by TBS in patients were compared with those observed in a control group of age-matched healthy individuals.RESULTS:
In patients, both the facilitatory TBS of the affected motor cortex and the inhibitory TBS of the unaffected motor cortex produced a significant increase of the amplitude of MEPs evoked by stimulation of the affected hemisphere. The effects observed in patients were comparable to those observed in controls.CONCLUSIONS:
Facilitatory TBS over the stroke hemisphere and inhibitory TBS over the intact hemisphere in acute phase enhance the excitability of the lesioned motor cortex.SIGNIFICANCE:
TBS might be useful to promote cortical plasticity in stroke patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Potencial Evocado Motor
/
Acidente Vascular Cerebral
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Estimulação Magnética Transcraniana
/
Córtex Motor
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Clin Neurophysiol
Assunto da revista:
NEUROLOGIA
/
PSICOFISIOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article