Natalizumab alters transcriptional expression profiles of blood cell subpopulations of multiple sclerosis patients.
J Neuroimmunol
; 194(1-2): 153-64, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18178259
ABSTRACT
Natalizumab, the most recently approved treatment for relapsing multiple sclerosis (MS) exerts its action through binding to alpha4 integrins. We studied longitudinally gene expression profiles in peripheral blood of MS patients, treated with natalizumab for more than 2 years. The majority of altered genes relates to immune response, signal transduction, adhesion and metabolism. Not only gene expression relevant for T lymphocytes was altered, but also genes regulating B-lymphocyte, neutrophil and erythrocyte functions. Understanding these different gene effects and their interrelationships will provide more insights into additional mechanisms of action of natalizumab and possibly allow better prediction of adverse events.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Células Sanguíneas
/
Regulação da Expressão Gênica
/
Anticorpos Monoclonais
/
Esclerose Múltipla
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Suíça