Selective nicotinic acetylcholine receptor agonists: potential therapies for neuropsychiatric disorders with cognitive dysfunction.
Curr Opin Investig Drugs
; 9(1): 47-56, 2008 Jan.
Article
em En
| MEDLINE
| ID: mdl-18183531
ABSTRACT
Cognitive impairment is one of the most functionally debilitating aspects of neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease, despite treatment with available pharmacotherapies. There is emerging evidence that nicotine improves cognitive function in humans and nonhuman species and this has sparked interest in the development of novel nicotinic treatments for cognitive dysfunction. The examination of selective alpha7 and alpha4beta2 nicotinic acetylcholine receptor (nAChR) agonists suggests that both receptor subtypes mediate improvement in attention, learning and working memory. When compared with available pharmacotherapies, specific nAChR agonists may represent unique targets for the treatment of neuropsychiatric and neurodegenerative disorders that feature cognitive impairment as a key symptom.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Receptores Nicotínicos
/
Transtornos Cognitivos
/
Agonistas Nicotínicos
/
Doença de Alzheimer
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Investig Drugs
Assunto da revista:
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos