Biotechnological applications of brown spider (Loxosceles genus) venom toxins.
Biotechnol Adv
; 26(3): 210-8, 2008.
Article
em En
| MEDLINE
| ID: mdl-18207690
ABSTRACT
Loxoscelism (the term used to define accidents by the bite of brown spiders) has been reported worldwide. Clinical manifestations following brown spider bites are frequently associated with skin degeneration, a massive inflammatory response at the injured region, intravascular hemolysis, platelet aggregation causing thrombocytopenia and renal disturbances. The mechanisms by which the venom exerts its noxious effects are currently under investigation. The whole venom is a complex mixture of toxins enriched with low molecular mass proteins in the range of 5-40 kDa. Toxins including alkaline phosphatase, hyaluronidase, metalloproteases (astacin-like proteases), low molecular mass (5.6-7.9 kDa) insecticidal peptides and phospholipases-D (dermonecrotic toxins) have been identified in the venom. The purpose of the present review is to describe biotechnological applications of whole venom or some toxins, with especial emphasis upon molecular biology findings obtained in the last years.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Venenos de Aranha
/
Aranhas
/
Biotecnologia
/
Diester Fosfórico Hidrolases
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biotechnol Adv
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Brasil