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Widespread inhibition proportional to excitation controls the gain of a leech behavioral circuit.
Baca, Serapio M; Marin-Burgin, Antonia; Wagenaar, Daniel A; Kristan, William B.
Afiliação
  • Baca SM; Section of Neurobiology, Division of Biological Sciences University of California, San Diego La Jolla, CA 92093-0357.
  • Marin-Burgin A; Section of Neurobiology, Division of Biological Sciences University of California, San Diego La Jolla, CA 92093-0357.
  • Wagenaar DA; Section of Neurobiology, Division of Biological Sciences University of California, San Diego La Jolla, CA 92093-0357.
  • Kristan WB; Section of Neurobiology, Division of Biological Sciences University of California, San Diego La Jolla, CA 92093-0357.
Neuron ; 57(2): 276-289, 2008 Jan 24.
Article em En | MEDLINE | ID: mdl-18215624
Changing gain in a neuronal system has important functional consequences, but the underlying mechanisms have been elusive. Models have suggested a variety of neuronal and systems properties to accomplish gain control. Here, we show that the gain of the neuronal network underlying local bending behavior in leeches depends on widespread inhibition. Using behavioral analysis, intracellular recordings, and voltage-sensitive dye imaging, we compared the effects of blocking just the known lateral inhibition with blocking all GABAergic inhibition. This revealed an additional source of inhibition, which was widespread and increased in proportion to increasing stimulus intensity. In a model of the input/output functions of the three-layered local bending network, we showed that inhibiting all interneurons in proportion to the stimulus strength produces the experimentally observed change in gain. This relatively simple mechanism for controlling behavioral gain could be prevalent in vertebrate as well as invertebrate nervous systems.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Sanguessugas / Atividade Motora / Inibição Neural Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Comportamento Animal / Sanguessugas / Atividade Motora / Inibição Neural Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Neuron Assunto da revista: NEUROLOGIA Ano de publicação: 2008 Tipo de documento: Article