Functional analysis of the Drosophila immune response during aging.
Aging Cell
; 7(2): 225-36, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18221416
ABSTRACT
One of the most dramatic changes associated with aging involves immunity. In aging mammals, immune function declines and chronic inflammation develops. The biological significance of this phenomenon and its relationship with aging is a priority for aging research. Drosophila is an invaluable tool in understanding the effects of aging on the immune response. Similar to the state of chronic inflammation in mammals, Drosophila exhibits a drastic up-regulation of immunity-related genes with age. However, it remains unclear whether immune function declines with age as seen in mammals. We evaluated the impact of aging on Drosophila immune function by examining across age the ability to eliminate and survive different doses of bacterial invaders. Our findings show that aging reduces the capacity to survive a bacterial infection. In contrast, we found no evidence that aging affects the ability to eliminate bacteria indicating that the mechanisms underlying immune senescence are not involved in eliminating bacteria or preventing their proliferation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Drosophila
/
Imunidade Inata
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Aging Cell
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá