Diagnosis of muscular glycogenosis by in vivo natural abundance 13C NMR spectroscopy.
Neuromuscul Disord
; 1(2): 99-101, 1991.
Article
em En
| MEDLINE
| ID: mdl-1822788
ABSTRACT
Natural abundance 13C NMR (nuclear magnetic resonance) spectroscopy was used to distinguish patients suffering from muscle glycogenosis type V (McArdle's disease) from normal subjects by measuring their muscle glycogen content at rest. Proton-decoupled 13C spectra were obtained in 10-15 min from calf muscles at rest. The ratio of the glycogen/creatine signal areas was 12.9 +/- 1.7 in four McArdle's disease patients and 2.0 +/- 0.7 in seven normal subjects. This technique thus allows the non-invasive diagnosis of muscle glycogenosis.
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Base de dados:
MEDLINE
Assunto principal:
Doença de Depósito de Glicogênio Tipo V
Tipo de estudo:
Diagnostic_studies
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neuromuscul Disord
Assunto da revista:
NEUROLOGIA
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França