DNA replication timing data corroborate in silico human replication origin predictions.
Phys Rev Lett
; 99(24): 248102, 2007 Dec 14.
Article
em En
| MEDLINE
| ID: mdl-18233493
ABSTRACT
We develop a wavelet-based multiscale pattern recognition methodology to disentangle the replication- from the transcription-associated compositional strand asymmetries observed in the human genome. Comparing replication skew profiles to recent high-resolution replication timing data reveals that most of the putative replication origins that border the so-identified replication domains are replicated earlier than their surroundings whereas the central regions replicate late in the S phase. We discuss the implications of this first experimental confirmation of these replication origin predictions that are likely to be early replicating and active in most tissues.
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Base de dados:
MEDLINE
Assunto principal:
Reconhecimento Automatizado de Padrão
/
Genoma Humano
/
Replicação do DNA
/
Modelos Genéticos
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
França