Poor reproducibility of template bleeding time in horses.
J Vet Intern Med
; 22(1): 238-41, 2008.
Article
em En
| MEDLINE
| ID: mdl-18289318
ABSTRACT
BACKGROUND:
Template bleeding time (TBT) is considered to be a useful test for detecting platelet function disorders and the effect of platelet-activating drugs, but studies in human medicine have concluded that the test has poor reproducibility and sensitivity.HYPOTHESIS:
TBT has poor reproducibility in horses and has insufficient sensitivity to detect the effect of etamsylate on platelet function. ANIMALS Twenty healthy horses.METHODS:
TBT was determined and repeated 2 hours and 30 days later. TBT was also performed 2 hours after IV administration of etamsylate.RESULTS:
Although no statistical differences were seen between the TBT values obtained at different times, the coefficients of variation for TBT replicates ranged from 26.8% to 45.5%. The reference range for TBT was 138.4-860.4 seconds. No statistically significant shortening of the mean TBT value was observed after etamsylate administration. CONCLUSION AND CLINICAL IMPORTANCE TBT has poor reproducibility, and the reference range is too wide to make TBT useful in a clinical setting. Other tests with higher reproducibility should be considered when assessing platelet function disorders in horses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tempo de Sangramento
/
Hemostáticos
/
Etamsilato
/
Hemorragia
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Vet Intern Med
Assunto da revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Espanha