[Macroscopic subtypes of asbestosis in relation to the amount of asbestos in 63 Japanese autopsy cases].
Nihon Kokyuki Gakkai Zasshi
; 46(2): 77-84, 2008 Feb.
Article
em Ja
| MEDLINE
| ID: mdl-18318247
ABSTRACT
Atelectatic induration (AI) and honeycombing (HNCB) are two distinct macroscopic features of asbestosis. The current study was undertaken to clarify whether or not there might be a relation between the macroscopic type of asbestosis and burden of asbestos fibers in the lung. The material (N = 63) derived from 58 autopsies and 5 surgically removed lungs with lung cancers, which comprised 22 cases of AI (mean age 67 years 20 males and 2 females) and 41 cases of HNCB (mean age 66 years 38 men and 3 women) types of asbestosis, respectively. The quantification of asbestos bodies (AB) and fibers (AF) was carried out using Kohyama's method. The AI type showed 260,000 +/- 460,000 AB per 1g of wet lung and 920,000 +/- 1,360,000 AF per 1g of dry lung, whereas HNCB showed 44,000 +/- 93,000 AB and 200,000 +/- 490,000 AF, respectively. These differences were statistically significant between the types of asbestosis (p < 0.01). Diffuse pleural thickening and upper lobe involvement were more advanced in the AI type and the differences were statistically significant between subtypes (p < 0.05). In conclusion, asbestos load is considered to be a factor related to the macroscopic subtype of asbestosis.
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Base de dados:
MEDLINE
Assunto principal:
Amianto
/
Asbestose
/
Exposição Ambiental
/
Pulmão
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Ja
Revista:
Nihon Kokyuki Gakkai Zasshi
Ano de publicação:
2008
Tipo de documento:
Article